One person is dead after a single vehicle crash near West Mississippi Avenue and South Santa Fe Drive.

Denver police say the crash happened just before 2 a.m. Tuesday. The driver and only occupant of the vehicle was pronounced dead at the scene.

The intersection was closed because of the crash investigation but has since reopened.

Police have not yet said if speed or alcohol may have been factors in the deadly crash.

Stay tuned to 9NEWS for updates in this developing story.