This Murphy guy with his Law is starting to irritate the Broncos.

Running back C.J. Anderson was out for the San Diego Chargers game Sunday and then some with a torn meniscus in his right knee, and wouldn’t you know it, his replacement Devontae Booker didn’t get through the game-opening series without suffering a shoulder injury.

It appeared Booker hurt his left shoulder while trying to catch a pass from Trevor Siemian near the Chargers’ goal line. Siemian was tackled down during the incompletion by San Diego cornerback Brandon Flowers.

To Booker’s credit, he tried not to favor his shoulder in front of nearly 76,000 fans at soon-to-be-renamed Sports Authority Field at Mile High or those tuning in on the regional telecast.

But the Broncos had no choice but to send Booker into the locker room for treatment. Whatever they did, it worked. Kapri Bibbs filled in for one, three-and-out series and then Booker returned

The rookie Booker had a tremendous 18-yard run in the fourth quarter, although the yards were otherwise hard to come by as he finished with 54 yards on 19 carries.

Booker was one of the last players to leave the trainer’s room after the game and Broncos head coach Gary Kubiak said the running back underwent more tests Monday.

“Everything sounds good,’’ Kubiak said during his day-after-game press conference Monday. “He’s sore. We’ll see where he’s at but the fact he was able to come back and play through it, I think is a good sign.’’

The Broncos need Booker for their AFC West first-place showdown with the Oakland Raiders this Sunday night at Oakland in a game that will kickoff at 6:30 on 9NEWS.

Booker runs with a lead-with-the-shoulder style so it was impressive he was banging his shoulder pads on 18 more carries and four more receptions after his injury.

As for that Murphy guy, he wasn’t through with the Broncos. Cornerback Aqib Talib was out against the Chargers with a back injury and naturally Murphy’s Law had the Broncos losing backup cornerback Kayvon Webster to a hamstring injury in the first quarter.