Tens of thousands of pounds of steel on wheels rolled down the highway with no driver at the wheel.
Anheuser-Busch, the truck creating company Otto and CDOT all say it can be done.
The self-driving truck already made one successful beer run in the middle of the night.
Wednesday, 9NEWS spoke to the team working on the project.
"I think we just need to keep proving that we can drive better than a human and we can handle a lot of different scenarios," Senior Program Manager Matt Grigsby said. "I think the big push is safety. We're trying to save lives like there's a lot of distracted driving out there and a lot of the accidents are because of human mistakes."
"The benefits are that this is a safer way of moving loads on the highway," James Sembrot with Anheuser-Busch said. "It's a more environmentally sustainable, and it offers operational efficiency that are important not only to the trucking industry, but to shippers as well."
Self-driving beer truck makes delivery in Colorado
The first successful beer route went from Fort Collins to Colorado Springs -- 120 miles.
The truck uses a computer to regulate speed and lane changing.
The operators say that can help with fuel efficiency.
But, these trucks aren't ready for everyday operation yet.
Tests in bad weather are still needed, and changes to the law would be required.