A neighbor says it sounded like a bridge collapse when an RTD bus crashed into a house in the Elyria-Swansea neighborhood of Denver on Tuesday afternoon.

Denver Fire says four people on the bus were taken to the hospital, but they couldn't say how badly they were injured.

The crash happened around 4 p.m. near Josephine Street and East 45th Avenue -- about a block away from the Purina Pet Care facility off Interstate 70.

A photo tweeted by Denver Fire shows the bus in contact with the front of the home with the windshield hanging off the front.

Phillip Lucas, a public affairs specialist with RTD, told 9NEWS a car rear-ended the bus, causing it to crash into the home.

The driver of the that car walked away without injuries. Denver Fire says there were children playing around the house, but none of them were hurt either.