Police are on the scene of a hit-and-run wreck in Denver.

It happened around 6:30 a.m. at the intersection of Speer Boulevard and Arapahoe Street.

At least one person has been transported with serious injuries. No description of a suspect car has been released.

Northbound Speer Boulevard was closed at Arapahoe for about 4 hours during the investigation. It reopened just before 10:30 a.m.

9NEWS will update this story as more information is available.