Two people are dead after a five-car wreck closed Interstate 70 going eastbound in Golden for several hours Sunday.

Colorado State Patrol says a pickup headed west crossed into the eastbound lanes around 11 a.m. before hitting an SUV, spinning around and hitting three more cars.

The 52-year-old driving the SUV, Jodie Stewart of Idaho Springs, died at the scene. Six people had serious injuries after the wreck, and just after 7:30 p.m. Sunday authorities say another person has died: 54-year-old Jeffery Stumpf of Evergreen.

Stumpf was driving the pickup that started the wreck.

Three others were taken to St. Anthony's Hospital with serious injuries. Another had moderate and a seventh person had minor injuries, troopers say.

Troopers tell 9NEWS it's unclear at this time why Stumpf crossed into oncoming traffic. Troopers continue to investigate.

I-70 eastbound was closed at mile-marker 259, which is the Morrison exit. It fully re-opened around 6:15 pm.