Thick black smoke rose from the building Monday as ambulances rushed to the scene.
Paramedics say one person was killed and several wounded. It's the second strike on the building in two days.
The Hamas TV station, Al Aqsa, is located on the top floor. Israeli aircraft have struck several crowded areas in the Gaza Strip, driving up the Palestinian death toll to 94 and devastating several homes belonging to one clan as Israel broadened its targets in the 6-day-old offensive.
Hamas fighters also have fired hundreds of rockets into Israel in the current round of fighting, including 75 on Monday, one that hit an empty school.
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