Both directions of Arapahoe Road at the I-25 intersection were closed, as well as the southbound interstate exit ramp, for about two hours during the investigation. The crash happened around 2:30 a.m.
Greenwood Village police are investigating alcohol, drugs and a high rate of speed as possible factors in the accident.
Police won't yet confirm the extent of the injuries. Stay tuned to the networks of 9NEWS for the latest information.
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