Angeleana Tyler was taken from Cheyenne by her mother, Misty Lea Stricker-Campos.
Authorities are especially concerned because Tyler has epilepsy and does not have her medication with her.
Police believe Stricker-Campos is heading to Mexico with Tyler. The two are on foot and may be hitchhiking or taking a bus through Colorado.
The 2-year-old was wearing a brown colored sweater, brown colored pants and pink colored shoes when she was taken.
Sticker-Campos was last seen wearing a black colored T-shirt, gray colored sweatpants with a green colored backpack
If you observe them do not make contact and call your local police or sheriff's office or dial 911.
(KUSA-TV © 2012 Multimedia Holdings Corporation)