The crowd of 3,408 stormed the floor shortly after the final buzzer sounded.
Jen Reese added 11 points and sealed the win with a rebound basket for Colorado (9-0), which beat a top 10 team for the first time since defeating No. 2 Stanford in the round of 16 during the 2002 NCAA tournament.
The Buffaloes are 62-142 against ranked opponents. They are also off to a 9-0 start for the fourth time, and the second straight year.
Antonita Slaughter paced Louisville (9-2) with 19 points. Shawnta Dyer had 14 points for the Cardinals, who lost for the second time in three games.
(Copyright 2012 The Associated Press. All rights reserved.)