The president arrived at Buckley Air Force Base in Aurora just shortly before 3 p.m.
His visit to Colorado is in support for Sen. Michael Bennet, who faces a challenge from former House Speaker Andrew Romanoff.
He appeared at a public reception at the Fillmore Auditorium around just before 4 p.m. and spoke for a little more than a half hour.
"We do not quit," Obama said.
Obama's message was intended not just for those inside Fillmore Auditorium or throughout the state. He aimed to persuade people listening nationwide that Democrats are more interested in fixing daily problems than engaging in petty squabbling.
"Michael and I, we don't have time for that nonsense," Obama said in his latest distancing from Washington's political culture. "We're going to keep doing everything in our power to keep turning this economy around."
Obama recognized Bennet as a reformer, saying he has been an "agent of change" who knows how to make the private sector work.
The president says Bennet fought for fiscal reform in Congress and supported the creation of a bipartisan fiscal commission.
Bennet criticized the bailout of big banks and said small businesses need capital now.
The Fillmore is located near Clarkson Street and Colfax Avenue in Denver.
After leaving the Fillmore, Obama went to a private fundraiser at the downtown Sheraton Hotel, located near 16th Street and Court Place.
He left Colorado from Buckley Air Force Base around 6:20 p.m.
Because of security surrounding the president, there could be road closures and traffic delays in the areas he plans to visit.
(KUSA-TV © 2010 Multimedia Holdings Corporation with The Associated Press)