The fire burned late Tuesday night at a duplex in Conyers, east of Atlanta.
Police say another child, who is 6, was thrown by his mother from a second-floor window. He survived but injured his shoulder.
Glenn Allen, a spokesman for Georgia's fire commissioner, tells The Associated Press the mother was taken to Grady Memorial Hospital in Atlanta with second- and third-degree burns.
Allen says seven people were in the home: a grandmother, the mother and five children. Conyers police Major Mike Waters told reporters the children who died range in age from an infant to 7 years old.
Allen says there's no indication to what caused the blaze.
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