Organizers announced Thursday that The Boss will address participants at a March 15 event at the Austin Convention Center.
Previous keynote speakers include Johnny Cash, Carl Perkins, Lucinda Williams, Robert Plant, Smokey Robinson and Neil Young.
South by Southwest begins March 9 with interactive and film events. The music festival stars March 13, showcasing more than 2,000 acts from around the world at dozens of stages throughout downtown Austin.
Springsteen and his E Street Band hit the road next year for a worldwide tour.
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