The children's' TV channel said Monday that the GOP presidential contender declined be involved in the special, while President Barack Obama participated.
The program includes videotaped questions for the candidates from children nationwide. Afterward, viewers can vote for their pick for president.
Linda Ellerbee, the show's host and producer, said candidates show "respect for kids" by answering their questions and called Romney's decision disappointing.
The Romney campaign did not immediately respond to phone and email requests for comment.
In the Nickelodeon special, Obama is asked about issues including jobs, immigration and bullying. It debuts Oct. 15.
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