HEMPSTEAD, NY - OCTOBER 16: U.S. President Barack Obama waves to the audience prior to the start of a town hall style debate at Hofstra University October 16, 2012 in Hempstead, New York. During the second of three presidential debates, the candidates fielded questions from audience members on a wide variety of issues. (Photo by John Moore/Getty Images)
NBC says Wednesday night's appearance will be Obama's fifth on "The Tonight Show," his third since he became president.
Obama has been making the late-night rounds as the presidential campaign has picked up steam. He was on CBS' "Late Show With David Letterman" last month, and chatted with Jon Stewart on Comedy Central's "The Daily Show" last week.
Mitt Romney has avoided the late-night talk shows since he became the Republican party's presidential nominee. But his wife, Ann, did appear on "The Tonight Show" last month.
(Copyright 2012 by The Associated Press. All Rights Reserved.)