McCaskill's victory denies Republicans a seat they'd hoped to pick up before Akin's comments.
Democrats have picked up two Senate seats from the Republicans - Elizabeth Warren in Massachusetts and Joe Donnelly in Indiana - while the GOP has lost three seats, including to an independent in Maine.
As of 10:45 p.m. Eastern time, Democrats had locked up 45 seats, Republicans 42, including 67 seats not up for election. Democrats now hold a 53-seat majority, including two independents who align with them.
(Copyright 2012 by The Associated Press. All Rights Reserved.)