Bishop Sankey atoned for a first-half fumble at the 1 by running through Colorado's defense for 139 yards and collecting 48 more on four receptions as the Huskies (7-4, 5-3 Pac-10) won consecutive road games for just the second time in the last decade.
The Huskies can secure their first eight-win season since 2001 with a win at Washington State next week.
After committing five costly turnovers in this one, the Buffaloes (1-10, 1-7) will have to beat Utah on Friday to avoid the worst record in school history and their first winless season at home since 1920.
Price completed 22 of 29 passes for 248 yards with no interceptions.
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