Brewer hit four of his six 3-pointers in the final 12-plus minutes, helping the Nuggets hold off the Lakers, whose five-game winning streak was snapped.
Bryant, who hit 40 points for the 116th time in his career, has scored 30 or more points in 10 straight games.
Kenneth Faried had 21 points and 15 rebounds, and Danilo Gallinari added 19 points for Denver. Ty Lawson had 17 points to go with 14 assists, and Andre Iguodala also scored 17 points.
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