The fatal accident occured in the northbound lanes of the highway between Illinois and Lake Avenues.
Pueblo Police say witnesses think the driver fell asleep, went off the road, hit a light pole, two fences and then his Expedition rolled several times.
The spokesperson for the police department 9NEWS talked with said he thought around seven people were in the SUV and that several, including the 9-year-old that died, were ejected. Everyone else in the crash only suffered minor injuries.
The name of the child has not been released. Police say the Expedition had been driving to or through Colorado from New Mexico.
The investigation into the accident is ongoing.