At 1:45 a.m., a single vehicle was exiting the southbound Interstate 70 ramp to the southbound Wadsworth Boulevard exit when the crash occurred.
Five of the people inside the vehicle sustained minor injuries. One person was critically injured.
The occupants in the vehicle range in age from 13 to 29.
Police say alcohol was a factor in the crash. A 20-year-old driver was taken in to custody.
One lane of the exit ramp was closed Thursday morning as authorities investigated the scene.