Supporters point to tax revenue and school funding as advantages of the law. Some economic development officials say not so fast.
"We think this could be pretty dramatically negative for our state," Ryan Schaefer, who runs Chrisland Commercial Real Estate, said.
Schaefer says he and many other business professionals are very concerned about Amendment 64.
"It allows corporate site selectors and executives a reason to de-select Northern Colorado on a short list of states," he said.
Sandra Hagen Solin represents the Chambers of Commerce of Fort Collins, Loveland and Greeley.
"We're very concerned," Solin said. "We were disappointed in the passage of the amendment and the way in which it creates a significant amount of uncertainty for business."
"I don't think that's what Colorado wants to be known for," Schaefer said." I don't think that's the message that our economic development officials and our governor have worked so hard to get out."
Economic experts do say it's likely there could be some pot tourism.
Some commercial vacancies may even go away with these shops that will likely start popping up sometime next year.
However, the crux of the issue is that Amendment 64, they say, will keep business away that otherwise might locate in Colorado.