The actors will be the hosts of the 19th annual event, to be held Dec. 11 in Oslo, Norway. Jennifer Hudson and Seal are among the performers.
The European Union captured the prize this year.
Parker says she is honored to "promote the power of peace around the world. Butler said the European Union has shown "the world what is possible when forces unite in peace" and called the concert a "remarkable celebration of humanity."
Past winners of the Nobel Peace Prize include Nelson Mandela, Mother Teresa, former Vice President Al Gore and President Barack Obama.