The Twilight Saga: Breaking Dawn -- Part 2, the final installment of the cinematic vampire love story, invades theaters on more than 4,000 screens.
Analysts expect the movie to open to about $145 million, which would beat the mark set by The Twilight Saga: New Moon. That film opened to $143 million in 2009 and went on to make $297 million.
Since Twilight opened in 2008, the franchise has racked up $1.1 billion in North America and more than $2.5 billion worldwide.
While no other new movie will challenge the young bloodsuckers this weekend, the Disney biopic Lincoln will expand to 1,500 theaters as it gears up for an Oscar run.
Forecasters expect the Daniel Day-Lewis film to collect $12 million.