To avoid the worst record since the program's inception in 1890, the Buffs will have to upset Utah, which was installed as a three-touchdown favorite Friday at Folsom Field.
The Utes were also a 21-point favorite a year ago when the Buffaloes ended their division title hopes with a 17-14 win at Salt Lake City to end a school-record 23-game road losing streak.
If the Utes (4-7, 2-6 Pac-12) win, the Buffaloes (1-10, 1-7) will go winless at home for the first time since 1920.
The Buffaloes have been outscored by an average of 46-16, and they've lost seven straight since their lone win, 35-34 at Washington State. During that streak, they've allowed an average of more than 50 points.