The crash happened near I-25 and 92nd Avenue in Thornton just after 6 p.m. The accident backed up traffic for miles.
Investigators say the teen was driving a Jeep Cherokee with four juvenile passengers when he hit the center median and flipped the SUV onto its roof.
All five were taken to the hospital. Their injuries are not serious. The relationship between the driver and the other passengers are not known. Police say the driver was arrested.
All lanes of I-25 northbound in that area reopened shortly after 9 p.m.