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Up to 75 CDOT snowplows were expected to begin working 12 hours shifts in the metro area late Tuesday as the storm moved into the area. Interstate 25 will be their main focus.

"Any snow storm can be different and can bring in different elements. If temperatures drop quickly or the snow comes in very hard and quick, which we're expecting, that could be challenging for our crews," CDOT Spokesperson Mindy Crane said. "I guarantee our crews will be staying overnight and continue to work on the roadways."

Forecasts call for up to 6 inches of snow along the Front Range, which is home to 4.1 million of Colorado's 5 million residents.

The storm has already caused treacherous driving conditions in western Colorado Tuesday that prompted officials to close Colorado 65 over the 11,333-foot Grand Mesa near Grand Junction.

Denver International Airport officials say blowing snow and low visibility were expected to cause delays Wednesday.