Adrian set the pool record in the 100 free, finishing in 48.32 seconds.
Matt Biondi held the previous record with 48.42 set in 1988.
Adrian dominated the field as fellow Olympians Ricky Berens and Jimmy Feigen finished in second and third, respectively. Berens finished in 49.35 and Feigen in 50.01.
Franklin won the first event of the evening, the women's 100 free in a time of 54.68. Simone Manuel took second place in 55.52, with Nathalie Lindborg from rounding out the top three in 56.16.