Three Colorado politicians were aboard a train carrying Republican lawmakers to a retreat in West Virginia Wednesday morning when the train struck what appeared to be a garbage truck.

Sen. Cory Gardner (R-Colorado), Rep. Mike Coffman (R-Colorado), and Rep. Scott Tipton (R-Colorado) were all on the train but were not injured, 9NEWS has confirmed.

"We ask for prayers for all involved in this accident & appreciate everyone's calls," a tweet from Coffman's staff read.

Coffman told 9NEWS he was facing the rear of the train at the time of the crash, and said it felt like he got punched in the back.

"I'm sorry for the loss of life today, but I think things clearly could've been a lot worse," Coffman said. "... I've never experienced anything like this before. At first it was kinda hard to figure out what it was."

There is one confirmed fatality and one serious injury from the crash, White House Press Secretary Sarah Sanders said, but no serious injuries among members of Congress or their staff.

According to Amtrak, the train collided with a vehicle on the tracks in Crozet, Va., a town about 126 miles away from Washington, D.C.

President Donald Trump, who is also scheduled to travel to West Virginia on Air Force One for the Republican retreat Thursday, has been fully briefed and is receiving regular updates, Sanders said.