Police said at 8:07 a.m. that officers were on the scene of the crash near the intersection of East Evans Avenue and South Oneida Street.
The bus was going west on East Evans Avenue when it hit a man while he was crossing the road mid-block, police said.
> Video above from November: Denver marks most traffic deaths since start of Vision Zero
The man was taken to the hospital with serious injuries, where he was pronounced dead, according to police.
The school bus did not have any students onboard at the time of the accident, and the driver stayed at the scene and is cooperating with investigators, police said.
The victim will be identified by the Denver Office of the Medical Examiner.
> Top stories from 9NEWS curated daily just for you! Sign up for the 9NEWSLETTER right now to get can’t-miss stories, Next and Broncos content, weather and more delivered right to your inbox.
SUGGESTED VIDEOS: Latest from 9NEWS
MORE WAYS TO GET 9NEWS
Subscribe to our daily 9NEWSLETTER for top stories from 9NEWS curated daily just for you. Get content and information right now for can’t-miss stories, Next and Broncos content, weather and more delivered right to your inbox.
HOW TO ADD THE 9NEWS APP TO YOUR STREAMING DEVICE
ROKU: add the channel from the ROKU store or by searching for KUSA.
For both Apple TV and Fire TV, search for "9NEWS" to find the free app to add to your account. Another option for Fire TV is to have the app delivered directly to your Fire TV through Amazon.