The Lions (6-2) sacked Tebow seven times and turned his two turnovers into touchdowns as they snapped a two-game skid.
Cornerback Chris Houston had the fourth 100-yard interception return in team history and defensive end Cliff Avril got the sack, the strip and the scoop, rumbling 24 yards into the end zone with the fumbled football as part of Detroit's 45-point run after the Broncos (2-5) had taken a 3-0 lead on their first drive.
Photos: Tailgaters show spirit before scary game
Lions linebacker Stephen Tulloch celebrated his sack of Tebow by joining the "Tebowing" craze, striking a prayerful pose near a prone second-year quarterback in the first half.
Tebow started the phenomenon that went viral last week by dropping to a knee after his dazzling comeback against the Dolphins, when he brought the Broncos back from a 15-0 deficit in the final three minutes to force overtime, where the team pulled out an 18-15 win.
There was no let-up by the Lions, who relished in their taunts of Tebow, who has been sacked 13 times in his two starts since supplanting Kyle Orton after a 1-4 start.
Tight end Tony Scheffler performed a scaled-down version of the Tebow impersonation after catching a 1-yard TD pass against his former team in the second quarter.
Scheffler, who set up the score with a juggling 28-yard catch at the 2, faked the spike, acted like he was going to kneel and put his right hand on his forehead a la Tebow, then spun around and exchanged the "Mile High Salute" with teammate Calvin Johnson instead.
Matthew Stafford hardly showed any ill effects from a sprained right ankle sustained a week earlier in a loss to Atlanta.
Stafford completed 21 of 30 passes for 267 yards and three touchdowns, including a 56-yarder to Johnson, who beat Champ Bailey down the delirious Detroit sideline. Johnson joined Randy Moss as the only wide receivers since the 1970 AFL-NFL merger to catch 11 TD passes in his team's first eight games.
Stafford also threw a 41-yard touchdown pass to Titus Young, who slipped behind safety Brian Dawkins and cornerback Andre' Goodman. No defender was within 20 yards when he hauled in Stafford's pass to give Detroit a 7-3 lead.
Jason Hanson's 50-yard field goal made it 10-3 and capped a drive in which Stafford scrambled for 21 yards and was awarded another 15 when hit in the head by Brodrick Bunkley while sliding.
The Broncos started off by mixing up offensive looks, but they ended up pretty vanilla as the game started to get away from them.
After Eric Decker failed to get both feet down on a 21-yard toss into the end zone on Denver's first drive, the Broncos settled for a field goal. Denver gained just 32 yards on its next 22 snaps before trudging into the locker room down 24-3.
Decker's 14-yard touchdown catch in the fourth quarter ended Detroit's 45-0 run. By then, even most of the fans decked out in No. 15 Tebow jerseys were streaming through the exits.
Thanks to completions in the waning minutes, Tebow finished 18 for 39 for 172 yards. He would have been sacked an eighth time had tackle Chris Clark not held him up long enough to fire off an incompletion while defensive end Willie Young tried to pull him down.
Ndamukong Suh pushed the pocket all afternoon, but had a rather quiet day stats-wise. Suh will spend part of his upcoming bye week meeting with NFL Commissioner Roger Goodell to get a better understanding why he's been flagged so many times this season.
(Copyright 2011 The Associated Press. All rights reserved.)